Hong Kong Journal of Nephrology
Volume 9, Issue 1 , Pages 3-6, April 2007

Somewhere Over the Rainbow: From Bedside to Bench

  • Kar-Neng Lai

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint requests to: Professor Kar-Neng Lai, Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China. Fax: (+852) 2816-2863

Yu Chiu Kwong Chair of Internal Medicine, Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China

Article Outline

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Suggested Reading 

  1. Leung JC , Tsang AW , Chan DT , Lai KN . Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells . J Am Soc Nephrol . 2000;11:241–249
  2. Leung JC , Tang SC , Lam MF , Chan TM , Lai KN . Charge dependent binding of polymeric IgA1 to human mesangial cell in IgA nephropathy . Kidney Int . 2001;59:277–285
  3. Lai KN , Chan LY , Tang SC , Tsang AW , Guo H , Tse KC , et al.   Characteristics of polymeric lambda-IgA binding to leukocytes in IgA nephropathy . J Am Soc Nephrol . 2002;13:2309–2319
  4. Leung JC , Tang SC , Chan LY , Tsang AW , Lan HY , Lai KN . Polymeric IgA increases the synthesis of macrophage migration inhibitory factor by human mesangial cells in IgA nephropathy . Nephrol Dial Transplant . 2003;18:36–45
  5. Lai KN , Tang SC , Guh JY , Chuang TD , Lam MF , Chan LY , et al.   Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin–angiotensin system . J Am Soc Nephrol . 2003;14:3127–3131
  6. Lai KN , Chan LY , Tang SC , Tsang AW , Li FF , Lam MF , et al.   Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 . Kidney Int . 2004;66:1403–1416
  7. Chan LY , Leung JC , Tsang AW , Tang SC , Lai KN . Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy . Kidney Int . 2005;67:602–612
  8. Chan LY , Leung JC , Tang SC , Choy CB , Lai KN . Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy . J Am Soc Nephrol . 2005;16:2306–2317
  9. Lai AS , Lai KN . Molecular basis of IgA nephropathy . Curr Mol Med . 2005;5:475–487
  10. Lai KN , Lai KB , Chan TM , Lam CW , Li FK , Leung JCK . Changes of cytokine profile during peritonitis in patients on continuous ambulatory peritoneal dialysis . Am J Kidney Dis . 2000;35:644–652
  11. Yanez-Mo M , Lara-Pezzi E , Selgas R , Ramirez-Huesca M , Dominguez-Jimenez C , Jimenez-Heffernan JA , et al.   Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells . N Engl J Med . 2003;348:403–413
  12. Lai KN , Leung JC , Chan LY , Li FF , Tang SC , Lam MF , et al.   Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products . Clin Exp Immunol . 2004;138:466–475
  13. Axelsson J , Rashid Qureshi A , Suliman ME , Honda H , Pecoits-Filho R , Heimburger O , et al.   Truncal fat mass as a contributor to inflammation in end-stage renal failure . Am J Clin Nutr . 2004;80:1222–1229
  14. Leung JC , Chan LY , Li FF , Tang SC , Chan KW , Chan TM , et al.   Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF . Nephrol Dial Transplant . 2005;20:1336–1349
  15. Friedman AN . Adiposity in dialysis; good or bad? . Seminar Dial . 2006;19:136–140
  16. Leung JC , Chan LY , Tang SC , Chu KM , Lai KN . Leptin induces TGF-beta synthesis through functional leptin receptor expressed by human peritoneal mesothelial cell . Kidney Int . 2006;69:2078–2086
  17. Fraser JK , Wulur I , Alfonso Z , Hedrick MH . Fat tissue: an underappreciated source of stem cells for biotechnology . Trends Biotechnol . 2006;24:150–154

PII: S1561-5413(07)60002-7

doi:10.1016/S1561-5413(07)60002-7

Hong Kong Journal of Nephrology
Volume 9, Issue 1 , Pages 3-6, April 2007

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