Hong Kong Journal of Nephrology
Volume 9, Issue 1 , Pages 23-30 , April 2007

Warfarin Versus Aspirin in Preventing Tunneled Hemodialysis Catheter Thrombosis: A Prospective Randomized Study

  • Ibrahiem Saeed Abdul-Rahman

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint request to: Dr. Ibrahiem Saeed, Nephrology Division, Department of Internal Medicine, King Fahd Hospital of the University, P.O. Box 40032, Al Khobar 31952, Saudi Arabia. Fax: (+966) 3-8966741
  • ,
  • Abdulla K. Al-Howaish

References 

  1. Windus DW . Permanent vascular access: a nephrologist's view . Am J Kidney Dis . 1993;21:457–471
  2. Hakim R , Himmelfarb J . Hemodialysis access failure: a call to action . Kidney Int . 1998;54:1029–1040
  3. Smits JH , van der Linden J , Blankestijn PJ , Rabelink TJ . Coagulation and haemodialysis access thrombosis . Nephrol Dial Transplant . 2000;15:1755–1760
  4. Feldman HI , Kobrin S , Wasserstein A . Hemodialysis vascular access morbidity . J Am Soc Nephrol . 1996;7:523–535
  5. Feldman HI , Held PJ , Hutchinson JT , Stoiber E , Hartigan MF , Berlin JA . Hemodialysis vascular access morbidity in the United States . Kidney Int . 1993;43:1091–1096
  6. Bern MM , Lokich JJ , Wallach SR , Bothe A , Benotti PN , Arkin CF , et al.   Very low doses of warfarin can prevent thrombosis in central venous catheters. A randomized prospective trial . Ann Intern Med . 1990;112:423–428
  7. Boraks P , Seale J , Price J , Bass G , Ethell M , Keeling D , et al.   Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies . Br J Haematol . 1998;101:483–486
  8. Obialo CI , Conner AC , Lebon LF . Maintaining patency of tunneled hemodialysis catheters—efficacy of aspirin compared to warfarin . Scand J Urol Nephrol . 2003;37:172–176
  9. Haire WD , Lieberman RP , Lund GB , Edney JA , Kessinger A , Armitage JO . Thrombotic complications of silicone rubber catheters during autologous marrow and peripheral stem cell transplantation: prospective comparison of Hickman and Groshong catheters . Bone Marrow Transplant . 1991;7:57–59
  10. NKF-DOQI Clinical Practice Guidelines for Vascular Access. Guideline 23: treatment of tunneled cuffed catheter dysfunction . Am J Kidney Dis . 1997;30(Suppl 3):S175–S176
  11. Suhocki PV , Conlon PJ , Knelson MH , Harland R , Schwab SJ . Silastic cuffed catheters for hemodialysis vascular access: thrombolytic and mechanical correction of malfunction . Am J Kidney Dis . 1996;28:379–386
  12. Lund GB, Trerotola SO, Scheel PF, Savader SJ, Mitchell SE, Venbrux AC, et al. Outcome of tunneled hemodialysis catheters placed by radiologists . Radiology . 1996;198:467–472
  13. Rysz J , Majewska E , Stolarek RA , Banach M , Cialkowska-Rysz A , Baj Z . Increased levels of soluble TNF-alpha receptors and cellular adhesions molecules in patients undergoing bioincompatible hemodialysis . Am J Nephrol . 2006;26:437–444
  14. Agraharkar M , Isaacson S , Mendelssohn D , Muralidharan J , Mustata S , Zevallos G , et al.   Percutaneously inserted silastic jugular hemodialysis catheters seldom cause jugular vein thrombosis . ASAIO J . 1995;41:169–172
  15. Karnik R , Valentin A , Winkler WB , Donath P , Slany J . Duplex sonographic detection of internal jugular venous thrombosis after removal of central venous catheters . Clin Cardiol . 1993;16:26–29
  16. Cox K , Vesely TM , Windus DW . The utility of brushing dysfunctional hemodialysis catheters . JVIR . 2000;11:979–983
  17. Uldall R , Besley ME , Thomas A . Maintaining the patency OF double-lumen silastic jugular catheters for hemodialysis . Int J Artif Organs . 1993;16:37–40
  18. Zellweger M , Bouchard J , Raymond-Carrier S , Laforest-Renald A , Querin S , Madore F . Systemic anticoagulation and prevention of hemodialysis catheter malfunction . ASAIO J . 2005;51:360–365
  19. Merport M , Murphy TP , Egglin TK , Dubel GJ . Fibrin sheath stripping versus catheter exchange for the treatment of failed tunneled hemodialysis catheters: randomized clinical trial . J Vasc Interv Radiol . 2000;11:1115–1120
  20. O'Farrel LO , Griffith JW , Lang CM . Histologic development of the sheath that forms around long term implanted central venous catheters . J Parenter Enteral Nutr . 1996;20:156–158
  21. Haskal ZJ , Leen VH , Thomas-Hawkins C , Shlansky-Goldberg RD , Baum RA , Soulen MC . Transvenous removal of fibrin sheaths from tunneled hemodialysis catheters . J Vasc Interv Radiol . 1996;7:513–517
  22. Di Minno G , Martinez J , McKean ML , De La Rosa J , Burke JF , Murphy S . Platelet dysfunction in uremia. Multifaceted defect partially corrected by dialysis . Am J Med . 1985;79:552–559
  23. Eknoyan G , Brown CHD . Biochemical abnormalities of platelets in renal failure. Evidence of decreased platelet serotonin, adenosine diphosphate and Mg-dependent adenosine triphosphatase . Am J Nephrol . 1981;1:17–23
  24. Remuzzi G , Benigni A , Dodesini P , Schieppati A , Livio M , De Gaetano G , et al.   Reduced platelet thromboxane formation in uremia. Evidence for functional cyclooxygenase defect . J Clin Invest . 1983;71:762–768
  25. Escolar G , Cases A , Bastida E , Garrido M , Lopez J , Revert L , et al.   Uremic platelets have a functional defect affecting the interaction of von Willebrand factor with glycoprotein IIb-IIIa . Blood . 1990;76:1336–1340
  26. Gawaz MP , Dobos G , Spath M , Schollmeyer P , Gurland HJ , Mujais SK . Impaired function of platelet membrane glycoprotein IIb-IIIa in end-stage renal disease . J Am Soc Nephrol . 1994;5:36–46
  27. Lindahl TL , Lundahl J , Netre C . Studies of the platelet fibrinogen receptor in Glanzmann patients and uremic patients . Thromb Res . 1992;67:457–466
  28. Walkowiak B , Pawlowska Z , Michalak E , Cierniewski CS . Expression of fibrinogen receptors on platelets of uremic patients is correlated with the content of GPIIb and plasma level of creatinine . Thromb Haemost . 1994;71:164–168
  29. Sreedhara R , Itagaki I , Hakim RM . Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIb-IIIa receptors . Am J Kidney Dis . 1996;27:355–364
  30. Noris M , Remuzzi G . Uremic bleeding: closing the circle after 30 years of controversies? . Blood . 1999;94:2569–2574
  31. Simon DI , Stamler JS , Loh E , Loscalzo J , Francis SA , Creager MA . Effect of nitric oxide synthase inhibition on bleeding time in humans . J Cardiovasc Pharmacol . 1995;26:339–342
  32. Noris M , Remuzzi G . Physiology and pathophysiology of nitric oxide in chronic renal disease . Proc Assoc Am Physicians . 1999;111:602–610
  33. Vaziri ND . Effect of chronic renal failure on nitric oxide metabolism . Am J Kidney Dis . 2001;38:S74–S79
  34. Deguchi N , Ohigashi T , Tazaki H , Handa M , Ikeda Y . Haemodialysis and platelet activation . Nephrol Dial Transplant . 1991;6(Suppl 2):40–42
  35. Reverter JC , Escolar G , Sanz C , Cases A , Villamor N , Nieuwenhuis HK , et al.   Platelet activation during hemodialysis measured through exposure of p-selectin: analysis by flow cytometric and ultrastructural techniques . J Lab Clin Med . 1994;124:79–85
  36. Viener A , Aviram M , Better OS , Brook JG . Enhanced in vitro platelet aggregation in hemodialysis patients . Nephron . 1986;43:139–143
  37. Shrivastava D , Lundin AP , Dosunmu B , Rao TK , Beyer MM , Friedman EA . Salvage of clotted jugular vein hemodialysis catheters . Nephron . 1994;68:77–79
  38. Garofalo RS , Zaleski GX , Lorenz JM , Funaki B , Rosenblum JD , Leef JA . Exchange of poorly functioning tunneled permanent hemodialysis catheters . AJR AM J Roentgenol . 1999;173:155–158
  39. Haire WD , Lieberman RP . Thrombosed central venous catheters: restoring function with 6-hour urokinase infusion after failure of bolus urokinase . J Parenter Enteral Nutr . 1989;13:92–98
  40. Haire WD , Atkinson JB , Stephens LC , Kotulak GD . Urokinase versus recombinant tissue plasminogen activator in thrombosed central venous catheters: a double-blinded, randomized trial . Thromb Haemost . 1994;72:543–547
  41. Savader SJ , Haikal LC , Ehrman KO , Porter DJ , Oteham AC . Hemodialysis catheter-associated fibrin sheath: treatment with low dose rt-PA infusion . J Vasc Interv Radiol . 2000;11:1131–1136
  42. Brady PS , Spence LD , Levitin A , Mickolich CT , Dolmatch BL . Efficacy of percutaneous fibrin sheath stripping in restoring patency of tunneled hemodialysis catheters . AJR Am J Roentgenol . 1999;173:1023–1027
  43. Schon D , Whittman D . Managing the complications of long-term tunneled dialysis catheters . Semin Dial . 2003;16:314–322
  44. Beathard GA . Dysfunction of new catheters by old fibrin sheath . Semin Dial . 2004;17:243–244
  45. Mokrzycki MH , Jean-Jerome K , Rush H , Zdunek MP , Rosenberg SO . A randomized trial of minidose warfarin for the prevention of late malfunction in tunneled, cuffed hemodialysis catheters . Kidney Int . 2001;59:1935–1942
  46. Pierratos A , Ouwendyk M , Francoeur R , Vas S , Raj DS , Ecclestone AM , et al.   Nocturnal hemodialysis: three-year experience . J Am Soc Nephrol . 1998;9:859–868
  47. Twardowski ZJ . Stepwise anticoagulation with warfarin for prevention of intravenous catheter thrombosis . Hemodial Int . 2000;4:37–41
  48. Sagripanti A , Cupisti A , Baicchi U , Ferdeghini M , Morelli E , Barsotti G . Plasma parameters of the prothrombotic state in chronic uremia . Nephron . 1993;63:273–278
  49. Sagedal S , Hartmann A , Sundstrom K , Bjornsen S , Brosstad F . Anticoagulation intensity sufficient for haemodialysis does not prevent activation of coagulation and platelets . Nephrol Dial Transplant . 2001;16:987–993
  50. Wanner C , Zimmermann J , Quaschning T , Galle J . Inflammation, dyslipidemia and vascular risk factors in hemodialysis patients . Kidney Int . 1997;62:S53–S55
  51. De Lima JJ, Sesso R, Abensur H, Lopes HF, Giorgi MC, Krieger EM, et al. Predictors of mortality in long-term haemodialysis patients with a low prevalence of comorbid conditions . Nephrol Dial Transplant . 1995;10:1708–1713
  52. Rugman FP , Jenkins JA , Duguid JK , Maggs PB , Hay CR . Prothrombin fragment F1 + 2: correlation with cardiovascular risk factors . Blood Coagul Fibrinolysis . 1994;5:335–340

PII: S1561-5413(07)60005-2

doi: 10.1016/S1561-5413(07)60005-2

Hong Kong Journal of Nephrology
Volume 9, Issue 1 , Pages 23-30 , April 2007