Hong Kong Journal of Nephrology
Volume 9, Issue 1 , Pages 50-54, April 2007

Tubulointerstitial Nephritis and Uveitis Syndrome Associated with Renal Tryptaseand Chymase-positive Mast Cell Infiltration

Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan

Article Outline

We report the clinical course and immunohistochemical analysis of a patient who presented with tubulointerstitial nephritis and uveitis syndrome (TINU syndrome). The patient, a 40-year-old woman, was referred to our hospital with general fatigue and a slight fever from another hospital. Mast cells are closely related to the development of renal interstitial fibrosis in patients with glomerulonephritis. To determine the role of mast cells in renal interstitial injury in TINU patients, we performed immunohistochemical studies on renal biopsy specimens using anti-human tryptase and anti-human chymase antibodies specific for mast cells. Double immunostaining of tryptase and chymase was also performed in renal tissues. In double immunofluorescence, cells with both chymase and tryptase (MCtc) were marked in the regions of interstitial fibrosis in this patient. It appears that mast cells are one of the constitutive cells of interstitial fibrosis in patients with TINU syndrome.

Key words:  chymase , interstitial nephritis , mast cell , TINU , tryptase

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Dobrin RS , Vernier RL , Fish AL . Acute eosinophilic interstitial nephritis and renal failure with bone marrow lymph node granulomas and anterior uveitis. A new syndrome . Am J Med . 1975;59:325–333
  2. Vanhaesebrouck P , Carton D , De Bel CD , Praet M , Proesmans W . Acute tubulointerstitial syndrome (TINU syndrome) . Nephron . 1985;40:418–422
  3. Kondo S , Kagami S , Shimizu M , Kitamura A , Urushihara M , Satake N , et al.   The role of mast cells in acute tubulointerstitial nephritis with uveitis . Eur J Pediatr . 2003;162:496–499
  4. Kondo S , Kagami S , Kido H , Strutz F , Muller GA , Kuroda Y . Role of mast cell tryptase in renal interstitial fibrosis . J Am Soc Nephrol . 2001;12:1669–1676
  5. Ehara T , Shigematsu H . Contribution of mast cells to the tubulointerstitial lesions in IgA nephritis . Kidney Int . 1998;54:1675–1683
  6. Toth T , Toth-Jakatics R , Jimi S , Ihara M , Urata H , Takebayashi S . Mast cells in rapidly progressive glomerulonephritis . J Am Soc Nephrol . 1999;10:1498–1505
  7. Church MK , Levi-Schaffer F . The human mast cells: updates on cells and cytokines . J Allergy Clin Immunol . 1997;99:155–160
  8. Hiromura K , Kurosawa M , Yano S , Naruse T . Tubulointerstitial mast cell infiltration in glomerulonephritis . Am J Kidney Dis . 1998;32:593–599
  9. Ruger BM , Hasan Q , Greenhill NS , Davis PF , Dunbar PR , Neale TJ . Mast cells and type collagen in human diabetic nephropathy . Diabetologia . 1996;39:1215–1222
  10. Okazaki T , Hirota S , Xu ZD , Maeyama K , Nkama A , Kawano S , et al.   Increase of mast cells in the liver and lung may be associated with but not a cause of fibrosis: demonstration using mast cell-deficient Ws/Ws rats . Lab Invest . 1998;78:1431–1438
  11. Pesci A, Majori M, Piccoli ML, Casalini A, Curti A, Franchini D, et al. Mast cells in bronchiolitis obliterans organizing pneumonia: mast cell hyperplasia and evidence for extracellular release of tryptase . Chest . 1996;110:383–391
  12. Ruoss SJ , Hartmann T , Caughey GH . Mast cell tryptase is a mitogen for cultured fibroblasts . J Clin Invest . 1991;88:493–499
  13. Kurusu A , Suzuki Y , Horikoshi S , Shirato I , Tomino Y . Relationship between mast cells in the tubulointerstitium and prognosis of patients with IgA nephropathy . Nephron . 2001;89:391–397
  14. Toth T , Toth-Jakatics R , Jimi S , Takebayashi S . Increased density of interstitial mast cells in amyloid A renal amyloidosis . Modern Pathol . 2000;13:1020–1028

PII: S1561-5413(07)60010-6

doi:10.1016/S1561-5413(07)60010-6

Hong Kong Journal of Nephrology
Volume 9, Issue 1 , Pages 50-54, April 2007

Article Tools