Hong Kong Journal of Nephrology
Volume 10, Issue 1 , Pages 37-41, April 2008

Nephrotic Syndrome Secondary to Strongyloidiasis: A Common Infection with an Uncommon Presentation

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR.

Article Outline

Disseminated strongyloidiasis has often been linked with the use of immunosuppressants in patients with nephrotic syndrome. Nephrotic syndrome secondary to Strongyloides stercoralis infection, however, is a rare entity. Here, we present a case of nephrotic syndrome possibly caused by underlying S. stercoralis infection in a patient who received steroid therapy in a preceding asthmatic attack. Literature on associated sporadic reports is reviewed.

Key words:  nephrotic syndrome , Strongyloides stercoralis , strongyloidiasis

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References 

  1. Liu LX , Weller PF . Strongyloidiasis and other intestinal nematode infections . Infect Dis Clin North Am . 1993;7:655–682
  2. Gill GV , Welch E , Bailey JW . Chronic Strongyloides stercoralis infection in former British Far East prisoners of war . QJM . 2004;97:789–795
  3. Lam CS , Tong MK , Chan KM , Siu YP . Disseminated strongyloidiasis: a retrospective study of clinical course and outcome . Eur J Clin Microbiol Infect Dis . 2006;25:14–18
  4. Keiser PB , Nutman TB . Strongyloides stercoralis in the immunocompromised population . Clin Microbiol Rev . 2004;17:208–217
  5. Wu MP , Ko LY , Chen KC , Chiou CK , Kou YM . Disseminated strongyloidiasis: report of a case . J Formos Med Assoc . 1988;87:402–405
  6. Mori S , Konishi T , Matsuoka K , Deguchi M , Ohta M , Mizuno O , et al.   Strongyloidiasis associated with nephrotic syndrome . Intern Med . 1998;37:606–610
  7. Morimoto J , Kaneoka H , Sasatomi Y , Sato YN , Murata T , Ogahara S , et al.   Disseminated strongyloidiasis in nephrotic syndrome . Clin Nephrol . 2002;57:398–401
  8. Wong TY , Szeto CC , Lai FF , Mak CK , Li PK . Nephrotic syndrome in strongyloidiasis: remission after eradication with anthelmintic agents . Nephron . 1998;79:333–336
  9. Yee YK , Lam CS , Yung CY , Que TL , Kwan TH , Au TC , et al.   Strongyloidiasis as a possible cause of nephrotic syndrome . Am J Kidney Dis . 1999;33:e4
  10. Hsieh YP , Wen YK , Chen ML . Minimal change nephrotic syndrome in association with strongyloidiasis . Clin Nephrol . 2006;66:459–463
  11. Tsai HC , Lee SJ , Liu YC , Lin WR , Huang CK , Chen YS , et al.   Clinical manifestations of strongyloidiasis in southern Taiwan . J Microbiol Immunol Infect . 2002;35:29–36
  12. Woodring JH , Halfhill H , Reed JC . Pulmonary strongyloidiasis: clinical and imaging features . AJR Am J Roentgenol . 1994;12:537–542
  13. Ly MN , Bethel SL , Usmani AS , Lambert DR . Cutaneous Strongyloides stercoralis infection . J Am Acad Dermatol . 2003;49(2 Suppl):S157–S160
  14. Kalb RE , Grossman ME . Periumbilical purpura in disseminated strongyloidiasis . JAMA . 1986;256:1170–1171
  15. Wong B . Parasite disease in immunocompromised hosts . Am J Med . 1984;76:479–486
  16. Boatright MD , Wang BW . Clinical infection with Strongyloides stercoralis following etanercept use for rheumatoid arthritis . Arthritis Rheum . 2005;52:1336–1337
  17. Porto M , Al Cantara L , Leal M , Castro N , Carvalho E . Atypical clinical presentation of strongyloidiasis in a patient co-infected with human T-cell lymphotrophic virus type I . Am J Trop Med Hyg . 2005;72:124–125
  18. Loutfy MR , Wilson M , Keystone JS , Kain KC . Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area . Am J Trop Med Hyg . 2002;66:749–752
  19. Genta RM . Predictive value of an enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of strongyloidiasis . Am J Clin Pathol . 1988;89:391–394
  20. Sithithaworn P , Srisawangwong T , Tesana S , Daenseekaew W , Sithithawron J , Fujimaki Y , et al.   Epidemiology of Strongyloides stercoralis in north-east Thailand: application of the agar plate culture technique compared with the enzyme-linked immunosorbent assay . Trans R Soc Trop Med Hyg . 2003;97:398–402
  21. Grimbert P , Audard V , Remy P , Lang P , Sahali D . Recent approaches to the pathogenesis of minimal-change nephrotic syndrome . Nephrol Dial Transplant . 2003;18:245–248
  22. Hoyer JR , Vernier RL , Najarian JS . Recurrence of idiopathic nephrotic syndrome after renal transplantation . Lancet . 1972;2:343–348
  23. Lagrue G , Branellec A , Blanc C . A vascular permeability factor in lymphocyte culture supernatants from patients with nephrotic syndrome . Biomedicine . 1975;23:73–75
  24. Terashima A , Alvarez H , Tello R , Infante R , Freedman DO , Gotuzzo E . Treatment failure in intestinal strongyloidiasis: an indicator of HTLV-I infection . Int J Infect Dis . 2002;6:28–30

PII: S1561-5413(08)60017-4

doi:10.1016/S1561-5413(08)60017-4

Hong Kong Journal of Nephrology
Volume 10, Issue 1 , Pages 37-41, April 2008