Hong Kong Journal of Nephrology
Volume 10, Issue 1 , Pages 42-45, April 2008

Non-granulomatous Interstitial Nephritis in a Chinese Man with Sarcoidosis

  • Sze-Kit Yuen

      Affiliations

    • Departments of Medicine and Geriatrics, and Yan Chai Hospital, Hong Kong SAR.
    • Corresponding Author InformationCorrespondence to: Dr. Yuen Sze Kit, Department of Medicine and Geriatrics, Caritas Medical Centre, 111 Wing Hong Street, Sham Shui Po, Kowloon, Hong Kong SAR. Fax: (+852) 2959-3774;
    • ,
  • Chee-Wung Chow

      Affiliations

    • Departments of Medicine and Geriatrics, and Yan Chai Hospital, Hong Kong SAR.
    • ,
  • Yat-Wing Lee

      Affiliations

    • Departments of Radiology, Caritas Medical Centre, and Yan Chai Hospital, Hong Kong SAR.
    • ,
  • Sai-Ping Yong

      Affiliations

    • Departments of Medicine and Geriatrics, and Yan Chai Hospital, Hong Kong SAR.
    • ,
  • Mo-Lin Wong

      Affiliations

    • Departments of Medicine and Geriatrics, and Yan Chai Hospital, Hong Kong SAR.
    • ,
  • Lin-Kiu Lau

      Affiliations

    • Department of Pathology, Yan Chai Hospital, Hong Kong SAR.
    • ,
  • Fung-Yee Siu

      Affiliations

    • Departments of Medicine and Geriatrics, and Yan Chai Hospital, Hong Kong SAR.
    • ,
  • King-On Cheung

      Affiliations

    • Departments of Medicine and Geriatrics, and Yan Chai Hospital, Hong Kong SAR.

Article Outline

Clinical renal involvement in sarcoidosis is rare and has not been previously reported in Chinese patients. We report a case of non-granulomatous interstitial nephritis that presented with acute renal failure in a Chinese man with underlying sarcoidosis. Use of prednisolone led to dramatic renal improvement and partial resolution of his asymptomatic lung parenchymal lesions. Unfortunately, the patient subsequently died of cryptococcal meningitis and episodes of nosocomial pneumonia. One should closely monitor a patient with a presumptive diagnosis of sarcoidosis after embarking on treatment since infections like tuberculosis may mimic or coexist with the disease. This is particularly important in areas where sarcoidosis is exceedingly rare.

Key words:  acute renal failure , interstitial nephritis , non-granulomatous , sarcoidosis , steroid , tuberculosis

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PII: S1561-5413(08)60018-6

doi:10.1016/S1561-5413(08)60018-6

Hong Kong Journal of Nephrology
Volume 10, Issue 1 , Pages 42-45, April 2008

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