Hong Kong Journal of Nephrology
Volume 11, Issue 1 , Pages 9-13 , April 2009

Effect of Vitamin C (Ascorbic Acid) as an Antioxidant in Reducing Cellular Injury Following Renal Reperfusion in Wistar Rats

  • Nithyananda Aanantharya Vinodini

      Affiliations

    • Department of Physiology, Center for Basic Sciences, Kasturba Medical College, Bejai, India
    • Corresponding Author InformationCorrespondence to: N.A. Vinodini, Department of Physiology, Center for Basic Sciences, Kasturba Medical College, Bejai, Mangalore 575004, Karnataka, India
    • ,
  • Yogesh Tripathi

      Affiliations

    • Department of Physiology, Ghariyan Medical College, Faculty of Medicine, Al Jabal Al Gharbi University, Gharian, Libya
    • ,
  • Coimbatore Vasudevan Raghuveer

      Affiliations

    • Department of Pathology, Kasturba Medical College, Mangalore, India
    • ,
  • Kamath Asha

      Affiliations

    • Department of Community Medicine, Kasturba Medical College, Manipal, India

REFERENCES 

  1. Lee JI , Son HY , Kim MC . Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation . J Vet Sci . 2006;7:375–379
  2. Sekhon CS , Sekhon BK , Singh I , Orak JK , Singh AK . Attenuation of renal ischemia/reperfusion injury by a triple-drug combination therapy . J Nephrol . 2003;16:63–74
  3. McCord JM . Oxygen-derived free radicals in post-ischemic tissue injury . N Engl J Med . 1985;312:159–163
  4. Korthuis RJ , Granger DN , Townsley MI , Tayler AE . The role of oxygen-derived free radicals in ischemic-induced increases in canine skeletal muscle vascular permeability . Circ Res . 1985;57:599–609
  5. Walker PM , Lindsay TF , Labbe R , Mickle DA , Romaschin AD . Salvage of skeletal muscle with free radical scavengers . J Vasc Surg . 1987;5:68–75
  6. Smith JK , Carden DL , Grisham MB , Granger DN , Korthuis RJ . Role of iron in post ischemic microvascular injury . Am J Physiol . 1989;256(5 Pt 2):H1472–H1477
  7. Bozkurt AK . Alpha-tocopherol (vitamin E) and iloprost attenuate reperfusion injury in skeletal muscle ischemia/reperfusion injury . J Cardiovasc Surg . 2002;43:693–696
  8. Lehr HA , Messmer K . Rationale for the use of antioxidant vitamins in clinical organ transplantation . Transplantation . 1996;62:1197–1199
  9. Nagel E , Meyer zu Vilsendorf A , Bartels M , Pichlmayr R . Antioxidative vitamins in prevention of ischemia/reperfusion injury . Int J Vitam Nutr Res . 1997;67:298–306
  10. Chade AR, Rodriguez-Porcel M, Herrmann J, Krier JD, Zhu X, Lerman A, et al. Beneficial effects of antioxidant vitamins on the stenotic kidney . Hypertension . 2003;42:605–612
  11. Kartha VNR , Krishnamurthy S . Factors affecting in vitro lipid peroxidation in rat homogenate . Ind J Physiol Pharmacol . 1978;22:44–52
  12. Beutler E , Duron O , Kelly BM . Improved methods for the determination of glutathione . J Lab Clin Med . 1963;61:882–888
  13. Beauchamp C , Fridovich I . Superoxide dismutase. Improved assay and assay applicable to acrylamide gel . Ann Biochem . 1971;44:276–287
  14. Lowry OH , Roscbrought NJ , Faro AI , Randal RJ . Protein measurement with folin phenol reagent . J Biol Chem . 1951;193:265–275
  15. Lieberthal W , Levine JS . Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury . Am J Physiol . 1996;271:F477–F488
  16. Weight SC , Bell PR , Nicholson ML . Renal ischaemia-reperfusion injury . Br J Surg . 1996;83:162–170
  17. Gueler F , Gwinner W , Schwarz A , Haller H . Long-term effects of acute ischemia and reperfusion injury . Kidney Int . 2004;66:523–527
  18. Perico N , Cattaneo D , Sayegh MH , Remuzzis G . Delayed graft function in kidney transplantation . Lancet . 2004;364:814–827
  19. Seo MY , Lee SM . Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats . J Hepatol . 2002;36:72–77
  20. Kadkhodaee M , Aryamanesh S , Faghihi M , Zahmatkesh M . Protection of rat renal vitamin E levels by ischemic-preconditioning . BMC Nephrol . 2004;5:6
  21. Kim JH , Kang M , Cho C , Chung HS , Kang CW , Parvez S , et al.   Effects of Nelumbinis Semen on contractile dysfunction in ischemic and reperfused rat heart . Arch Pharm Res . 2006;29:777–785
  22. Iheanacho EN , Stocker R , Hunt NH . Redox metabolism of vitamin C in blood of normal and malaria-infected mice . Biochim Biophys Acta . 1993;1182:15–21
  23. Vita JA , Frei B , Holbrook M , Gokce N , Leaf C , Keaney JF . L-2-oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease . J Clin Invest . 1998;101:1408–1414
  24. Barja G , Lopez-Torres M , Perez-Campo R , Rojas C , Cadenas S , Prat J , et al.   Dietary vitamin C decreases endogenous protein oxidative damage, malondialdehyde, and lipid peroxidation and maintains fatty acid unsaturation in the guinea pig liver . Free Radic Biol Med . 1994;17:105–115
  25. Kimura H , Yamada Y , Morita Y , Ikeda H , Matsuo T . Dietary ascorbic acid depresses plasma and low density lipoprotein lipid peroxidation in genetically scorbutic rats . J Nutr . 1992;122:1904–1909
  26. Cadenas S , Lertsiri S , Otsuka M , Barja G , Miyazawa T . Phospholipid hydroperoxides and lipid peroxidation in liver and plasma of ODS rats supplemented with alpha-tocopherol and ascorbic acid . Free Radic Res . 1996;24:485–493
  27. Sies H , Stahl W , Sundquiste AR . Antioxidant functions of vitamins . Ann NY Acad Sci . 1992;669:7–20

PII: S1561-5413(09)60003-X

doi: 10.1016/S1561-5413(09)60003-X

Hong Kong Journal of Nephrology
Volume 11, Issue 1 , Pages 9-13 , April 2009

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