Hong Kong Journal of Nephrology
Volume 7, Issue 1 , Pages 9-13 , April 2005

Urotensin II and the Circulatory System

References 

  1. Bern HA , Pearson D , Larson BA , Nishioka RS . Neurohormones from fish tails: the caudal neurosecretory system. I. “Urophysiology” and the caudal neurosecretory system of fishes . Recent Prog Horm Res . 1985;41:533–552
  2. Ames RS , Sarau HM , Chambers JK , Willette RN , Aiyar NV , Romanic AM , et al.   Human urotensin II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 . Nature . 1999;401:282–286
  3. Onan D , Hannan RD , Thomas WG . Urotensin II: the old kid in town . Trends Endocrinol Metab . 2004;15:175–182
  4. Shenouda A , Douglas SA , Ohlstein EH , Giaid A . Localization of urotensin-II immunoreactivity in normal human kidneys and renal carcinoma . J Histochem Cytochem . 2002;50:885–889
  5. Protopopov A , Kashuba V , Podowski R , Gizatullin R , Sonnhammer E , Wahlestedt C , et al.   Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization . Cytogenet Cell Genet . 2000;88:312–313
  6. Maguire JJ , Kuc RE , Davenport AP . Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1 . Br J Pharmacol . 2000;131:441–446
  7. Saetrum Opgaard O , Nothacker H , Ehlert FJ , Krause DN . Human urotensin II mediates vasoconstriction via an increase in inositol phosphates . Eur J Pharmacol . 2000;406:265–271
  8. Sauzeau V , Le Mellionnec E , Bertoglio J , Scalbert E , Pacaud P , Loirand G . Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rhokinase . Circ Res . 2001;88:1102–1104
  9. Tamura K , Okazaki M , Tamura M , Isozumi K , Tasaki H , Nakashima Y . Urotensin II-induced activation of extracellular signal-regulated kinase in cultured vascular smooth muscle cells: involvement of cell adhesion-mediated integrin signaling . Life Sci . 2003;72:1049–1060
  10. Matsushita M , Shichiri M , Imai T , Iwashina M , Tanaka H , Takasu N , et al.   Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues . J Hypertens . 2001;19:2185–2190
  11. Zhang AY , Chen YF , Zhang DX , Yi FX , Qi J , Andrade-Gordon P , et al.   Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney . Am J Physiol Renal Physiol . 2003;285:F792–F798
  12. Bottrill FE , Douglas SA , Hiley CR , White R . Human urotensin-II is an endothelium-dependent vasodilator in rat small arteries . Br J Pharmacol . 2000;130:1865–1870
  13. Stirrat A , Gallagher M , Douglas SA , Ohlstein EH , Berry C , Kirk A , et al.   Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries . Am J Physiol Heart Circ Physiol . 2001;280:H925–H928
  14. Behm DJ , Doe CP , Johns DG , Maniscalco K , Stankus GP , Wibberley A , et al.   Urotensin-II: a novel systemic hypertensive factor in the cat . Naunyn Schmiedebergs Arch Pharmacol . 2004;369:274–280
  15. Bohm F , Pernow J . Urotensin II evokes potent vasoconstriction in humans In vivo . Br J Pharmacol . 2002;135:25–27
  16. Wilkinson IB , Affolter JT , de Haas SL , Pelligrini MP , Boyd J , Winter MJ , et al.   High plasma concentrations of human urotensin II do not alter local or systemic hemodynamics in man . Cardiovasc Res . 2002;53:341–347
  17. Affolter JT , Newby DE , Wilkinson IB , Winter MJ , Balment RJ , Webb DJ . No effect on central or peripheral blood pressure of systemic urotensin II infusion in humans . Br J Clin Pharmacol . 2002;54:617–621
  18. Russell FD , Molenaar P , O'Brien DM . Cardiostimulant effects of urotensin-II in human heart in vitro . Br J Pharmacol . 2001;132:5–9
  19. Affolter J , Webb DJ . Urotensin II: a new mediator in cardiopulmonary regulation? . Lancet . 2001;358:774–775
  20. Totsune K , Takahashi K , Arihara Z , Sone M , Satoh F , Ito S , et al.   Role of urotensin II in patients on dialysis . Lancet . 2001;358:810–811
  21. Richards AM , Nicholls MG , Lainchbury JG , Fisher S , Yandle TG . Plasma urotensin II in heart failure . Lancet . 2002;360:545–546
  22. Russell FD , Meyers D , Galbraith AJ , Bett N , Toth I , Kearns P , et al.   Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure . Am J Physiol Heart Circ Physiol . 2003;285:H1576–H1581
  23. Totsune K , Takahashi K , Arihara Z , Sone M , Ito S , Murakami O . Increased plasma urotensin II levels in patients with diabetes mellitus . Clin Sci . 2003;104:1–5
  24. Heller J , Schepke M , Neef M , Woitas R , Rabe C , Sauerbruch T . Increased urotensin II plasma levels in patients with cirrhosis and portal hypertension . J Hepatol . 2002;37:767–772
  25. Silvestre RA , Rodriguez-Gallardo J , Egido EM , Marco J . Inhibition of insulin release by urotensin II - a study on the perfused rat pancreas . Horm Metab Res . 2001;33:379–381
  26. Zhu F , Ji L , Luo B . The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population . Zhonghua Yi Xue Za Zhi . 2002;82:1473–1475 [In Chinese]
  27. Wenyi Z , Suzuki S , Hirai M , Hinokio Y , Tanizawa Y , Matsutani A , et al.   Role of urotensin II gene in genetic susceptibility to type 2 diabetes mellitus in Japanese subjects . Diabetologia . 2003;46:972–976
  28. Thompson JP , Watt P , Sanghavi S , Strupish JW , Lambert DG . A comparison of cerebrospinal fluid and plasma urotensin II concentrations in normotensive and hypertensive patients undergoing urological surgery during spinal anesthesia: a pilot study . Anesth Analg . 2003;97:1501–1503
  29. Cheung BM , Leung R , Man YB , Wong LY . Plasma concentration of urotensin II is raised in hypertension . J Hypertens . 2004;22:1341–1344
  30. Watanabe T , Pakala R , Katagiri T , Benedict CR . Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells . Circulation . 2001;104:16–18
  31. Watanabe T , Pakala R , Katagiri T , Benedict CR . Synergistic effect of urotensin II with serotonin on vascular smooth muscle cell proliferation . J Hypertens . 2001;19:2191–2196
  32. Zuo HH , Hong JM , Guo HS , Wei JR , He YH , Li ZL . Urotensin II induces hypertrophy of in vitro cultured neonatal rat cardiac myocytes . Di Yi Jun Yi Da Xue Xue Bao . 2004;24:642–645 [In Chinese]
  33. Onan D , Pipolo L , Yang E , Hannan RD , Thomas WG . Urotensin II promotes hypertrophy of cardiac myocytes via mitogen-activated protein kinases . Mol Endocrinol . 2004;18:2344–2354
  34. Douglas SA , Tayara L , Ohlstein EH , Halawa N , Giaid A . Congestive heart failure and expression of myocardial urotensin II . Lancet . 2002;359:1990–1997
  35. Ng LL , Loke I , O'Brien RJ , Squire IB , Davies JE . Plasma urotensin in human systolic heart failure . Circulation . 2002;106:2877–2880
  36. Lapp H , Boerrigter G , Costello-Boerrigter LC , Jaekel K , Scheffold T , Krakau I , et al.   Elevated plasma human urotensin-II-like immunoreactivity in ischemic cardiomyopathy . Int J Cardiol . 2004;94:93–97
  37. Lim M , Honisett S , Sparkes CD , Komesaroff P , Kompa A , Krum H . Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failure . Circulation . 2004;109:1212–1214
  38. He YH , Hong JM , Guo HS , Wei JR , Chen H , Zuo HH , et al.   Effects of urotensin II on cultured cardiac fibroblast proliferation and collagen type I mRNA expression . Di Yi Jun Yi Da Xue Xue Bao . 2004;24:505–508 [In Chinese]
  39. Zhang Y , Li J , Cao J , Chen J , Yang J , Zhang Z , et al.   Effect of chronic hypoxia on contents of urotensin II and its functional receptors in rat myocardium . Heart Vessels . 2002;16:64–68
  40. Tzanidis A , Hannan RD , Thomas WG , Onan D , Autelitano DJ , See F , et al.   Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophy . Circ Res . 2003;93:246–253

PII: S1561-5413(09)60174-5

doi: 10.1016/S1561-5413(09)60174-5

Hong Kong Journal of Nephrology
Volume 7, Issue 1 , Pages 9-13 , April 2005