Hong Kong Journal of Nephrology
Volume 7, Issue 1 , Pages 27-33 , April 2005

Classical Tolerance Induction in Renal Transplantation — A Study of 11 Patients

  • Hargovind L. Trivedi

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint requests to: Professor Hargovind L. Trivedi, Institute of Kidney Diseases & Research Centre and Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad 380-016, Gujarat, India. Fax: (+91) 79-2268-5454
    • ,
  • Javed M. Vakil
  • Aruna V. Vanikar

      Affiliations

    • Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Kidney Diseases & Research Centre and Institute of Transplantation Sciences, Ahmedabad, India
    • ,
  • Pranjal R. Modi

      Affiliations

    • Department of Urology and Transplantation Surgery, Institute of Kidney Diseases & Research Centre and Institute of Transplantation Sciences, Ahmedabad, India
    • ,
  • Veena R. Shah

      Affiliations

    • Department of Anesthesiology and Critical Care, Institute of Kidney Diseases & Research Centre and Institute of Transplantation Sciences, Ahmedabad, India
    • ,
  • Sajni I. Khemchandani

      Affiliations

    • Department of Urology and Transplantation Surgery, Institute of Kidney Diseases & Research Centre and Institute of Transplantation Sciences, Ahmedabad, India
    • ,
  • Varsha B. Trivedi

      Affiliations

    • Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Kidney Diseases & Research Centre and Institute of Transplantation Sciences, Ahmedabad, India
    • ,
  • Rashmi D. Patel

      Affiliations

    • Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Kidney Diseases & Research Centre and Institute of Transplantation Sciences, Ahmedabad, India

References 

  1. Trivedi HL , Shah VR , Shah PR , Darji P , Sane A , Vanikar A , et al.   High dose DBMC associated tolerance in live-related renal allograft recipients . Transplant Proc . 2000;32:2001–2002
  2. Trivedi HL , Shah VR , Shah PR , Sane AS , Vanikar AV , Trivedi VB , et al.   Megadose approach to DBMC infusion-induced allograft hyporesponsiveness in living-related renal allograft recipients . Transplant Proc . 2001;33:71–76
  3. Trivedi HL , Shah VR , Vanikar AV , Gera D , Shah PR , Trivedi VB , et al.   High-dose peripheral blood stem cell infusion: a strategy to induce donor-specific hyporesponsiveness to allografts in pediatric renal transplant recipients . Pediatr Transplant . 2002;6:63–68
  4. Trivedi H , Vanikar A , Shah V , Mehta A , Shah S , Shah T , et al.   Mega dose unfractionated donor bone marrow-derived cell infusion in thymus and periphery - an integrated clinical approach for tolerance in living related renal allografts . Transplant Proc . 2003;35:203–206
  5. Billingham RE , Brent L , Medawar PB . 'Actively acquired tolerance' of foreign cells . Nature . 1953;172:603–606
  6. Guzzetta PC , Sundt TM , Suzuki T , Mixon A , Rosengard BR , Sachs DH . Induction of kidney transplantation tolerance across major histocompatibility complex barriers by bone marrow transplantation in miniature swine . Transplantation . 1991;51:862–866
  7. Smith CV , Nakajima K , Mixon A , Guzzetta PC , Rosengard BR , Fishbein JM , et al.   Successful induction of long-term specific tolerance to fully allogeneic renal allografts in miniature swine . Transplantation . 1992;53:438–444
  8. Kawai T , Cosimi AB , Colvin RB , Powelson J , Eason J , Kozlowski T , et al.   Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys . Transplantation . 1995;59:256–262
  9. Kimikawa M , Sachs DH , Colvin RB , Bartholomew A , Kawai T , Cosimi AB . Modifications of the conditioning regimen for achieving mixed chimerism and donor-specific tolerance in cynomolgus monkeys . Transplantation . 1997;64:709–716
  10. Starzl TE , Zinkernagel RM . Transplantation tolerance from a historical perspective . Nat Rev Immunol . 2001;1:233–239
  11. Garcia-Morales R , Esquenazi K , Zucker K , Gomez CI , Fuller L , Carreno M , et al.   An assessment of the effects of cadaver donor bone marrow on kidney allograft recipient blood cell chimerism by a novel technique combining PCR and flow cytometry . Transplantation . 1996;62:1149–1160
  12. Garcia-Morales R , Carreno M , Mathew J , Zucker K , Cirocco R , Ciancio G , et al.   The effects of chimeric cells following donor bone marrow infusions as detected by PCR-flow assays in kidney transplant recipients . J Clin Invest . 1997;99:1118–1129
  13. Rugeles MT , Aitouche A , Zeevi A , Fung JJ , Watkins SC , Starzl TE , et al.   Evidence for the presence of multilineage chimerism and progenitors of donor dendritic cells in the peripheral blood of bone marrow-augmented organ transplant recipients . Transplantation . 1997;64:735–741
  14. Garcia-Morales R , Carreno M , Mathew J , Cirocco R , Zucker K , Ciancio G , et al.   Continuous observations on the regulatory effects of donor-specific bone marrow cell infusions and chimerism in kidney transplant recipients . Transplantation . 1998;65:956–965
  15. Sayegh MH , Fine NA , Smith JL , Rennke HG , Milford EL , Tilney NL . Immunologic tolerance to renal allografts after bone marrow transplants from the same donors . Ann Int Med . 1991;114:954–955
  16. Spitzer TR , Delmonico F , Tolkoff-Rubin N , McAfee S , Sackstein R , Saidman S , et al.   Combined histocompatibility leucocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism . Transplantation . 1999;68:480–484

PII: S1561-5413(09)60177-0

doi: 10.1016/S1561-5413(09)60177-0

Hong Kong Journal of Nephrology
Volume 7, Issue 1 , Pages 27-33 , April 2005

Article Tools