Hong Kong Journal of Nephrology
Volume 7, Issue 1 , Pages 34-37, April 2005

Idiopathic Membranous Glomerulonephritis in Patients with Type 2 Diabetes Mellitus

  • Faissal Tarrass

      Affiliations

    • Department of Nephrology, Ibn Rochd Hospital, Casablanca, Morocco
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr. Faissal Tarrass, Salama 3, Gr 6, B, N° 21, Casablanca 20450, Morocco
    • ,
  • Abbelkabir Anabi

      Affiliations

    • Department of Nephrology, Ibn Rochd Hospital, Casablanca, Morocco
    • ,
  • Mohamed Zamd

      Affiliations

    • Department of Nephrology, Ibn Rochd Hospital, Casablanca, Morocco
    • ,
  • Beyounes Ramdani

      Affiliations

    • Department of Nephrology, Ibn Rochd Hospital, Casablanca, Morocco
    • ,
  • Mohamed Gharbi Benghanem

      Affiliations

    • Department of Nephrology, Ibn Rochd Hospital, Casablanca, Morocco
    • ,
  • Driss Zaid

      Affiliations

    • Department of Nephrology, Ibn Rochd Hospital, Casablanca, Morocco
    • ,
  • Saida Sqalli

      Affiliations

    • Histopathology Laboratory, Ibn Rochd Hospital, Casablanca, Morocco
    • Department of Nephrology, Ibn Rochd Hospital, Casablanca, Morocco

Article Outline

The occurrence of membranous glomerulonephritis (MGN) in patients with type 2 diabetes mellitus (DM) is a rare event and of pathogenetic interest. We report two males (52 and 64 years old) with type 2 DM and nephrotic syndrome of recent onset. Renal biopsy was performed because of the unusual clinical pictures: microscopic hematuria; heavy proteinuria without evidence of diabetic retinopathy; and, in one case, a sudden onset of renal failure. Renal biopsy disclosed pure MGN without glomerulosclerosis. In both cases, clinical history, physical examination and biologic assessment failed to reveal the cause; MGN was thus considered idiopathic. Treatment, including glycemic control and angiotensin-II receptor blockers, led to resolution of proteinuria in one case. We suggest that renal biopsies should be performed in diabetic patients with a sudden onset of renal failure, proteinuria without retinopathy, or other evidence of microvascular disease.

Key words:  membranous glomerulonephritis , renal biopsy , type 2 diabetes mellitus

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PII: S1561-5413(09)60178-2

doi:10.1016/S1561-5413(09)60178-2

Hong Kong Journal of Nephrology
Volume 7, Issue 1 , Pages 34-37, April 2005

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