Hong Kong Journal of Nephrology
Volume 7, Issue 2 , Pages 65-69 , October 2005

Measurement of Whole Blood Tacrolimus Level by High Performance Liquid Chromatography Tandem Mass Spectrometry in Renal Transplant Recipients — A Single Center Perspective

  • Yiu-Han Chan

      Affiliations

    • Renal Unit, Department of Medicine, Prince of Wales Hospital, Hong Kong SAR, China
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr. Yiu-Han Chan, Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong SAR, China. Fax: (+852) 2384-4698
    • ,
  • Chung-Shun Ho

      Affiliations

    • Department of Chemical Pathology, Prince of Wales Hospital, Hong Kong SAR, China
    • Renal Unit, Department of Medicine, Prince of Wales Hospital, Hong Kong SAR, China
    • ,
  • Chi-Chung Shek

      Affiliations

    • Department of Pathology, Queen Elizabeth Hospital, Prince of Wales Hospital, Hong Kong SAR, China
    • Renal Unit, Department of Medicine, Prince of Wales Hospital, Hong Kong SAR, China
    • ,
  • Kim-Ming Wong

      Affiliations

    • Renal Unit, Department of Medicine, Prince of Wales Hospital, Hong Kong SAR, China
    • ,
  • Wai-Leung Chak

      Affiliations

    • Renal Unit, Department of Medicine, Prince of Wales Hospital, Hong Kong SAR, China
    • ,
  • Koon-Shing Choi

      Affiliations

    • Renal Unit, Department of Medicine, Prince of Wales Hospital, Hong Kong SAR, China
    • ,
  • Ka-Foon Chau

      Affiliations

    • Renal Unit, Department of Medicine, Prince of Wales Hospital, Hong Kong SAR, China
    • ,
  • Chun-Sang Li

      Affiliations

    • Renal Unit, Department of Medicine, Prince of Wales Hospital, Hong Kong SAR, China

References 

  1. Pirsch JD , Miller J , Deierhoi MH , Vincenti F , Filo RS . A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group . Transplantation . 1997;63:977–983
  2. Kershner RP , Fitzsimmons WE . Relationship of FK506 whole blood concentrations and efficacy and toxicity after liver and kidney transplantation . Transplantation . 1996;62:920–926
  3. Jusko WJ , Thomson AW , Fung J , McMaster P , Wong SH , Zylber-Katz E , et al.   Consensus document: therapeutic monitoring of tacrolimus (FK-506) . Ther Drug Monit . 1995;17:606–614
  4. Cogill JL , Taylor PJ , Westley IS , Morris RG , Lynch SV , Johnson AG . Evaluation of the tacrolimus II microparticle enzyme immunoassay (MEIA II) in liver and renal transplant recipients . Clin Chem . 1998;44:1942–1946
  5. Gonschior AK, Christians U, Braun F, Winkler M, Linck A, Baumann J, et al. Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA) . Br J Clin Pharmacol . 1994;38:567–571
  6. Taylor PJ , Jones A , Balderson GA , Lynch SV , Norris RL , Pond SM . Sensitive, specific quantitative analysis of tacrolimus (FK506) in blood by liquid chromatography-electrospray tandem mass spectrometry . Clin Chem . 1996;42:279–285
  7. Wong KM , Shek CC , Chau KF , Li CS . Abbreviated tacrolimus area-under-the-curve monitoring for renal transplant recipients . Am J Kidney Dis . 2000;35:660–666
  8. Bland JM , Altman DG . Statistical methods for assessing agreement between two methods of clinical measurement . Lancet . 1986;1:307–310
  9. Tamura K , Fujimura T , Iwasaki K , Sakuma S , Fujitsu T , Nakamura K , et al.   Interaction of tacrolimus (FK506) and its metabolites with FKBP and calcineurin . Biochem Biophys Res Commun . 1994;202:437–443
  10. Armstrong VW , Schuetz E , Zhang Q , Groothuisen S , Scholz C , Shipkova M , et al.   Modified pentamer formation assay for measurement of tacrolimus and its active metabolites: comparison with liquid chromatographytandem mass spectrometry and microparticle enzyme-linked immunoassay (MEIA-II) . Clin Chem . 1998;44:2516–2523
  11. Johnston A , Chusney G , Schutz E , Oellerich M , Lee TD , Holt DW . Monitoring cyclosporin in blood: between-assay differences at trough and 2 hours post-dose (C2) . Ther Drug Monit . 2003;25:167–173
  12. Takahara S , Kokado Y , Kameoka H , Takano Y , Jiang H , Moutabarrik A , et al.   Monitoring of FK 506 blood levels in kidney transplant recipients . Transplant Proc . 1994;26:2106–2108
  13. Filler G , Grygas R , Mai I , Stolpe HJ , Greiner C , Bauer S , et al.   Pharmacokinetics of tacrolimus (FK 506) in children and adolescents with renal transplants . Nephrol Dial Transplant . 1997;12:1668–1671

PII: S1561-5413(09)60216-7

doi: 10.1016/S1561-5413(09)60216-7

Hong Kong Journal of Nephrology
Volume 7, Issue 2 , Pages 65-69 , October 2005

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