Hong Kong Journal of Nephrology
Volume 8, Issue 2 , Pages 71-74 , October 2006

Characteristic Changes in Anti-erythropoietin Antibodies in a Peritoneal Dialysis Patient Who Developed Pure Red Cell Aplasia

  • Shu-Hong Bi

      Affiliations

    • Division of Nephrology, Peking University First Hospital, Beijing, P.R. China
    • Division of Nephrology, Peking University Third Hospital, Beijing, P.R. China
    • ,
  • Li-Tao Cheng

      Affiliations

    • Division of Nephrology, Peking University First Hospital, Beijing, P.R. China
    • ,
  • Wei Chen

      Affiliations

    • Division of Nephrology, Peking University First Hospital, Beijing, P.R. China
    • Division of Nephrology, Peking University Third Hospital, Beijing, P.R. China
    • ,
  • Tao Wang

      Affiliations

    • Division of Nephrology, Peking University First Hospital, Beijing, P.R. China
    • Division of Nephrology, Peking University Third Hospital, Beijing, P.R. China
    • Corresponding Author InformationAddress correspondence and reprint requests to: Dr. Tao Wang, Division of Nephrology, Third Hospital, Peking University, 49 North Garden Road, Haidian District, Beijing 100083, P.R. China. Fax: (+86) 10-82907314

References 

  1. Eckardt KU , Casadevall N . Pure red-cell aplasia due to anti-erythropoietin antibodies . Nephrol Dial Transplant . 2003;18:865–869
  2. Schellekens H . Immunogenicity of therapeutic proteins: clinical implications and future prospects . Clin Ther . 2002;24:1720–1740
  3. Casadevall N , Nataf J , Viron B , Kolta A , Kiladjian JJ , Martin-Dupont P , et al.   Pure red-cell aplasia and anti-erythropoietin antibodies in patients treated with recombinant erythropoietin . N Engl J Med . 2002;346:469–475
  4. Kharagjitsingh AV , Korevaar JC , Vandenbroucke JP , Boeschoten EW , Krediet RT , Daha MR , et al.   Incidence of recombinant erythropoietin (EPO) hyporesponse, EPO-associated antibodies, and pure red cell aplasia in dialysis patients . Kidney Int . 2005;68:1215–1222
  5. Wu G , Wadgymar A , Wong G , Ting R , Nathoo B , Mendelssohn D , et al.   A cross-sectional immunosurveillance study of anti-EPO antibody levels in CRF patients receiving epoetin alfa in 5 Ontario Renal Centers . Am J Kidney Dis . 2004;44:264–269
  6. Mayeux P , Billat C , Jacquot R . The erythropoietin receptor of rat erythroid progenitor lens. Characterization and affinity cross-linkage . J Biol Chem . 1987;262:13985–13990
  7. Asari A , Gokal R . Pure red cell aplasia secondary to epoetin alpha responding to Darbepoetin alpha in a patient on peritoneal dialysis . J Am Soc Nephrol . 2004;15:2204–2207
  8. Chng WJ , Tan LK , Liu TC . Cyclosporine treatment for patients with CRF who developed pure red blood cell aplasia following EPO therapy . Am J Kidney Dis . 2003;41:692–695
  9. Mandreoli M, Finelli C, Lopez A, Ascani S, Vianelli N, Baccarani M, et al. Successful resumption of epoetin alfa after rituximab treatment in a patient with pure red cell aplasia . Am J Kidney Dis . 2004;44:757–761
  10. Kadikoylu G , Bolaman Z , Barutca S . High-dose methylprednisolone therapy in pure red cell aplasia . Ann Pharmacother . 2002;36:55–58

PII: S1561-5413(09)60236-2

doi: 10.1016/S1561-5413(09)60236-2

Hong Kong Journal of Nephrology
Volume 8, Issue 2 , Pages 71-74 , October 2006

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