Hong Kong Journal of Nephrology
Volume 11, Issue 2 , Pages 41-46, October 2009

Complement Activation and Progression of Chronic Kidney Disease

  • Ziyong Tang

      Affiliations

    • Department of Nephrology, Peking University Third Hospital, Beijing, China
    • ,
  • Neil Sheerin

      Affiliations

    • Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    • Corresponding Author InformationCorrespondence to: Dr. Neil Sheerin, School of Clinical Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. Fax: (+44) 0191-2220723

Article Outline

Proteinuria is a strong predictor of progression in chronic kidney disease. Complement proteins are a major constituent of the urine of proteinuric patients. Complement is activated in the tubular lumen through the alternative pathway, and complement activation products are deposited on the apical surface of tubular epithelial cells. Recent animal studies have suggested that complement activation in the tubular compartment plays an important role in proteinuria-associated tubulointerstitial injury. Complement deficiency, depletion or inhibition all reduce the tubular cell damage and interstitial fibrosis that develops in proteinuric animals. In particular, inhibition of anaphylatoxin receptors protects the kidneys from proteinuria-associated damage. In this review, we discuss the evidence for a role of complement activation in the progression of chronic kidney disease.

Key words:  chronic kidney disease , complement activation , proteinuria

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PII: S1561-5413(09)60241-6

doi:10.1016/S1561-5413(09)60241-6

Hong Kong Journal of Nephrology
Volume 11, Issue 2 , Pages 41-46, October 2009

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