Volume 12, Issue 1, Pages 6-11 (April 2010)

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ABSTRACT

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Immunization in Renal Transplant Recipients: Where Do We Stand?

Infections are a major cause of morbidity and mortality in renal transplant recipients. Adequate vaccination strategies can prevent a majority of them. This review highlights the various vaccines, their dosing, schedule, efficacy and safety in renal transplant patients.

Key words: immunization , renal transplant , vaccination

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Article Outline

• Abstract

• References

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References

1. 1 Ambrosino DM , Molrine DC . Critical appraisal of immunization strategies for prevention of infection in the compromised host . Hematol Oncol Clin North Am . 1993;7:1027–1050 . MEDLINE

2. 2 Keane WR , Helderman JH , Luby J , Gailiunas P , Hull AR , Kokko JP . Epidemic renal transplant rejection associated with influenza A . Victoria Proc Clin Dial Transpl Forum . 1978;8:232–236 .

3. 3 Chesi C , Günther M , Huzly D , Neuhaus R , Reinke P , Engelmann HB , et al. Immunization of liver and renal transplant recipients: a seroepidemiological and sociodemographic survey . Transpl Infect Dis . 2009;11:507–512 . CrossRef

4. 4 Avery RK . Immunizations in adult immunocompromised patients: which to use and which to avoid . Cleveland Clin J Med . 2001;68:337–348 .

5. 5 Rytel MW , Dailey MP , Schiffman G , Hoffmann RG , Piering WF . Pneumococcal vaccine immunization of patients with renal impairment . Proc Soc Exp Biol Med . 1986;182:468–473 . MEDLINE

6. 6 Daum RS , Sood SK , Osterholm MT , Pramberg JC , Granoff PD , White KE , et al. Decline in serum antibody to the capsule of Haemophilus influenzae type b in the immediate post immunization period . J Pediatr . 1989;114:742–747 . Abstract | Full-Text PDF (475 KB) | CrossRef

7. 7 Duchini A , Goss JA , Karpen S , Pockros PJ . Vaccinations for adult solid organ transplant recipients: current recommendations and protocols . Clin Microbiol Rev . 2003;16:357–364 . MEDLINE | CrossRef

8. 8 Grob PJ , Jemelka HI , Binswanger U , Zaruba K , Descoeudres C , Fernex M . Interferon as an adjuvant for hepatitis B vaccination in non and low-responder populations . Eur J Clin Microbiol . 1984;3:195–198 . MEDLINE

9. 9 Meuer SC , Dumann H , Meyer zum Buschenfelde KH , Kohler T . Low dose interleukin-2 induces systemic immune response against hepatitis B virus surface antigen in immunodeficient non-responders to hepatitis B vaccination . Lancet . 1989;1:15–17 . MEDLINE

10. 10 Heineman TC , Clemens-Mann ML , Poland GA , Jacobson RM , Izu AE , Sakamoto D , et al. A randomized, controlled study in adults of the immunogenicity of a novel hepatitis B vaccine containing MF59 adjuvant . Vaccine . 1999;17:2769–2778 . CrossRef

11. 11 Gershon AA . Immunizations for pediatric transplant patients . Kidney Int . 1993;44:S87–S90 .

12. 12 Gabriel R , Selwyn S , Brown D , Crossland JM , Loughridge LW , Morgan MN , et al. Virus infection and acute renal transplant rejection . Nephron . 1976;16:282–286 .

13. 13 Huzly D , Neife S , Reinke P , Schroder K , Schonfeld C , Hofmann T , et al. Routine immunizations in adult renal transplant recipients . Transplantation . 1997;63:839–845 . MEDLINE | CrossRef

14. 14 Pirofski LA , Casadevall A . Use of licensed vaccines for active immunization of the immunocompromised host . Clin Microbiol Rev . 1998;11:1–26 . MEDLINE

15. 15 Hibberd PL , Rubin RH . Approach to immunization in the immunosuppressed host . Infect Dis Clin North Am . 1990;4:123–142 . MEDLINE

16. 16 Jacobson IM , Jaffers G , Dienstag JL , Tolkoff-Rubin NE , Cosimi AB , Delmonico F , et al. Immunogenicity of hepatitis B vaccine in renal transplant recipients . Transplantation . 1985;39:393–395 . MEDLINE | CrossRef

17. 17 Bruguera M , Rodicio JL , Alcazar JM , Oliver A , Del Rio G , Esteban-Mur R . Effects of different dose levels and vaccination schedules on immune response to a recombinant DNA hepatitis B vaccine in hemodialysis patients . Vaccine . 1990;8(Suppl):S47–S49 . CrossRef

18. 18 [No authors listed]. Recommendations for preventing transmission of infections among chronic hemodialysis patients . MMWR Recomm Rep . 2001;50:1–43 . MEDLINE

19. 19 Advisory Committee on Immunization Practices . Guidelines for Vaccinating Kidney Dialysis Patients and Patients With Chronic Kidney Disease . Available at http://www.cdc.gov/vaccines/pubs/downloads/bdialysis_guide.pdf [Date accessed: August 31, 2009] .

20. 20 Stevens CE , Alter HJ , Taylor PE , Zang EA , Harley EJ , Szmuness W . Hepatitis B vaccine in patients receiving hemodialysis. Immunogenicity and efficacy . N Engl J Med . 1984;311:496–501 . MEDLINE | CrossRef

21. 21 Banatvala J , Van Damme P , Van Hattum J . Boosters for hepatitis B. European Consensus Group on Hepatitis B Immunity . Lancet . 2000;356:337–338 . Full Text | Full-Text PDF (51 KB) | CrossRef

22. 22 Jadoul M , Goubau P . Is anti-hepatitis B virus (HBV) immunization successful in elderly hemodialysis (HD) patients? . Clin Nephrol . 2002;58:301–304 . MEDLINE

23. 23 Vagelli G , Calabrese G , Mazzotta A , Pratesi G , Gonella M . More about response to hepatitis B vaccine in hemodialysis patients . Nephron . 1988;49:171 .

24. 24 Anandh U , Bastani B , Ballal S . Granulocyte-macrophage colony-stimulating factor as an adjuvant to hepatitis B vaccination in maintenance hemodialysis patients . Am J Nephrol . 2000;20:53–56 . MEDLINE | CrossRef

25. 25 [No authors listed]. Guidelines for vaccination of solid organ transplant candidates and recipients . Am J Transplant . 2004;4(Suppl 10):S160–S163 .

26. 26 Stark K , Günther M , Neuhaus R , Reinke P , Schröder K , Linnig S . Immunogenicity and safety of hepatitis A vaccine in liver and renal transplant recipients . J Infect Dis . 1999;180:2014–2017 . MEDLINE | CrossRef

27. 27 Günther M , Stark K , Neuhaus R , Reinke P , Schröder K , Bienzle U , et al. Rapid decline of antibodies after hepatitis A immunization in liver and renal transplant recipients . Transplantation . 2001;71:477–479 . MEDLINE | CrossRef

28. 28 Sanchez-Fructuoso AI , Prats D , Naranjo P , Fernández-Pérez C , González MJ , Mariano A , et al. Influenza virus immunization effectivity in kidney transplant patients subjected to two different triple-drug therapy immunosuppression protocols: mycophenolate versus aza thioprine . Transplantation . 2000;69:436–439 . MEDLINE

29. 29 Birdwell KA , Ikizler MR , Sannella EC , Wang L , Bryne DW , Ikizler TA , et al. Decreased antibody response to influenza vaccination in kidney transplant recipients: a prospective cohort study . Am J Kidney Dis . 2009;54:112–121 . Abstract | Full Text | Full-Text PDF (457 KB) | CrossRef

30. 30 Scharpé J , Evenepoel P , Maes B , Bammens B , Claes K , Osterhaus AD , et al. Influenza vaccination is efficacious and safe in renal transplant recipients . Am J Transplant . 2008;8:332–337 . CrossRef

31. 31 Blumberg EA , Albano C , Pruett T , Isaacs R , Fitzpatrick J , Bergin J , et al. The immunogenicity of influenza virus vaccine in solid organ transplant recipients . Clin Infect Dis . 1996;22:295–302 . MEDLINE

32. 32 Keshtkar-Jahromi M , Argani H , Rahnavardi M , Mirchi E , Atabak S , Tara SA , et al. Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: a controlled trial . Am J Nephrol . 2008;28:654–660 . CrossRef

33. 33 Willcocks LC , Chaudhry AN , Smith JC , Ojha S , Doffinger R , Watson CJ , et al. The effect of sirolimus therapy on vaccine responses in transplant recipients . Am J Transplant . 2007;7:2006–2011 . CrossRef

34. 34 Candon S , Thervet E , Lebon P , Suberbielle C , Zuber J , Lima C , et al. Humoral and cellular immune responses after influenza vaccination in kidney transplant recipients . Am J Transplant . 2009;9:2346–2354 . CrossRef

35. 35 Centers for Disease Control and Prevention . Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine . MMWR Morb Mortal Wkly Rep . 2009;58:521–524 .

36. 36 Liang XF , Wang HQ , Wang JZ , Fang HH , Wu J , Zhu FC , et al. Safety and immunogenicity of 2009 pandemic influenza A H1N1 vaccines in China: a multicentre, double-blind, randomised, placebo-controlled trial . Lancet . 2010;375:56–66 . Abstract | Full Text | Full-Text PDF (160 KB) | CrossRef

37. 37 Plennevaux E , Sheldon E , Blatter M , Reeves-Hoché M-K , Denis M . Immune response after a single vaccination against 2009 influenza A H1N1 in USA: a preliminary report of two randomised controlled phase 2 trials . Lancet . 2010;375:41–48 . Abstract | Full Text | Full-Text PDF (131 KB) | CrossRef

38. 38 Al-Khayatt R , Jennings R , Potter C . Interpretation of responses and protective levels of antibody against attenuated influenza A viruses using single radial haemolysis . J Hyg (Lond) . 1984;93:301–312 . MEDLINE | CrossRef

39. 39 Gupta A , Ignatius A , Khaira A , Agarwal SK . Swine influenza: nephrologist's perspective . Iran J Kidney Dis . 2009;3:175–176 .

40. 40 Kumar D , Rotstein C , Miyata G , Arlen D , Humar A . Randomized, double-blind, controlled trial of pneumococcal vaccination in renal transplant recipients . J Infect Dis . 2003;187:1639–1645 . MEDLINE | CrossRef

41. 41 Kumar D , Welsh B , Siegal D , Chen MH , Humar A . Immunogenicity of pneumococcal vaccine in renal transplant recipients—three year follow-up of a randomized trial . Am J Transplant . 2007;7:633–638 . MEDLINE | CrossRef

42. 42 Pourfarziani V , Ramezani MB , Taheri S , Izadi M , Einollahi B . Immunogenicity of pneumococcal vaccination in renal transplant recipients and hemodialysis patients: a comparative controlled trial . Ann Transplant . 2008;13:43–47 .

43. 43 Kazancio'glu R , Sever MS , Yüksel-Onel D , Eraksoy H , Yildiz A , Celik AV , et al. Immunization of renal transplant recipients with pneumococcal polysaccharide vaccine . Clin Transplant . 2000;14:61–65 . MEDLINE | CrossRef

44. 44 Wong G , Howard K , Webster A , Chapman JR , Craig JC . The health and economic impact of cervical cancer screening and human papillomavirus vaccination in kidney transplant recipients . Transplantation . 2009;87:1078–1091 . CrossRef

45. 45 Avery RK , Michaels M . Update on immunizations in solid organ transplant recipients: what clinicians need to know . Am J Transplant . 2008;8:9–14 . CrossRef

46. 46 Zamora I , Simon JM , Da Silva ME , Piqueras AI . Attenuated varicella virus vaccine in children with renal transplants . Pediatr Nephrol . 1994;8:190–192 . CrossRef

47. 47 Chaves Tdo S , Lopes MH , de Souza VA , Dos Santos SdeS , Pereira LM , Reis AD , et al. Seroprevalence of antibodies against varicellazoster virus and response to the varicella vaccine in pediatric renal transplant patients . Pediatr Transplant . 2005;9:192–196 . MEDLINE | CrossRef

48. 48 Huzly D , Neifer S , Reinke P , Schröder K , Schönfeld C , Hofmann T , et al. Routine immunizations in adult renal transplant recipients . Transplantation . 1997;63:839–845 . MEDLINE | CrossRef

49. 49 Enke BU , Bökenkamp A , Offner G , Bartmann P , Brodehl J . Response to diphtheria and tetanus booster vaccination in pediatric renal transplant recipients . Transplantation . 1997;64:237–241 . MEDLINE | CrossRef

50. 50 Duchini A , Goss JA , Karpen S , Pockros PJ . Vaccinations for adult solid-organ transplant recipients: current recommendations and protocols . Clin Microbiol Rev . 2003;16:357–364 . MEDLINE | CrossRef

51. 51 Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group . KDIGO clinical practice guideline for the care of kidney transplant recipients . Am J Transplant . 2009;9(Suppl 3):S1–155 . CrossRef

Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India

Correspondence to: Dr. Ankur Gupta, Department of Nephrology, All India Institute of Medical Sciences, Ansar Nagar, New Delhi 110029, India

PII: S1561-5413(10)60003-8

doi:10.1016/S1561-5413(10)60003-8

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